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which of the following occurs because ran-gef is found in the nucleus? question 2 options: ran binds a molecule of gtp (releasing gdp), and binds the nuclear import receptor ran binds a molecule of gtp (releasing gdp), and releases the nuclear import receptor ran binds a molecule of gdp (releasing gtp), and binds the nuclear import receptor ran binds a molecule of gdp (releasing gtp), and releases the nuclear import receptor

Answer :

Ran binds a molecule of gtp (releasing gdp), and releases the nuclear import receptor occurs because ran-gef is found in the nucleus.

Ran was mainly found in the nucleus and hence was designated the Ras-related nuclear protein.Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that are involved in the activation of small GTPases. Small GTPases act as molecular switches on intracellular signaling pathways and have many downstream targets. RAN-GDP plus exportin receptor, again through the pores inside the nucleus is recalled. RAN-GEF is a protein found within the nucleus that adds one additional phosphate group to the RAN-GDP complex. It results in the release of the exportin receptor and the formation of the RAN-GTP complex.

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