Answer :
list the provides the correct enzyme order required for nucleotide excision repair of a thymine dimer is nuclease, DNA polymerase, DNA ligase.
Base excision repair (BER) involves the removal of the damaged base by the glycosylase enzyme followed by the removal of the phosphate in the backbone by AP endonucleases. The proper nucleotide is then replaced by DNA polymerase beta (), and the break is then repaired by DNA ligase enzymes.
Five fundamental processes comprise the repair procedure: (1) base excision; (2) incision; (3) end processing; and (4) repair synthesis, including gap filling and ligation. Image 3. The structural underpinnings of how BER enzymes interact with their DNA substrates.
To repair DNA with AP sites or base damage, BER only needs four or five enzymes in the fundamental reaction steps. One DNA glycosylase, one AP endonuclease, one DNA polymerase, and one DNA ligase are among these. BER begins with the removal of a damaged base by the DNA glycosylase.
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