Outline the mechanism of the conversion of α-ketoglutarate to succinyl-CoA catalyzed by α-ketoglutarate dehydrogenase complex.
Put these 5 steps in order:
1. decarboxylation
2. transacylation
3. dihydrolipoyl dehydrogenase activity
4. oxidation of 4-carbon group, reduction of lipoamide disulfide
5. enzymatical FADH2 reoxydation by NAD+

The oxidative decarboxylation of -ketoglutarate to succinyl coenzyme A is catalyzed by the -ketoglutarate dehydrogenase complex (ODHC) (succinyl-CoA).

What kind of reaction is catalyzed by alpha-ketoglutarate dehydrogenase?

A tightly controlled enzyme called alpha-ketoglutarate dehydrogenase (-KGDH) may control the metabolic flow through the Krebs cycle. It directly creates NADH and catalyzes the conversion of -ketoglutarate to succinyl-CoA, supplying the respiratory chain with electrons.

Does alpha-ketoglutarate dehydrogenase get inhibited by succinyl-CoA?

The -ketoglutarate dehydrogenase complex does not have a sophisticated regulation system comprising a kinase and a phosphatase, in contrast to the pyruvate dehydrogenase complex. High ratios of ATP/ADP, succinyl-CoA/CoASH, and NADH/NAD+, on the other hand, inhibit activity while Ca2+ stimulates it.

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