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Malonate is a competitive inhibitor of succinate dehydrogenase. If malonate is added to a mitochondrial preparation that is oxidizing pyruvate as a substrate, which compound would you expect to decrease in concentration?.

Answer :

The compound whose concentration decreases will be Fumarate

Malonate is a competitive inhibitor of succinate dehydrogenase, meaning it binds to the enzyme's active site without reacting and so competes with succinate, the enzyme's substrate. As a result, the chemical malonate reduces cellular respiration.

Succinate dehydrogenases catalyze the reaction succinate + Q ⇌ fumarate + QH2, which serves as a vital link between the tricarboxylic acid cycle and oxidative phosphorylation.

So Malonate binds with the active site of the enzyme without reacting, and hence competes with succinate, the usual substrate of the enzyme.

Therefore the concentration of Fumarate decreases.

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