A possible rationale for the difference between the DNA in chromatin and chromosome form is the structure of chromatin, loosely organized chromatin and condensed chromatin.
Chromatin is a macromolecular structure composed of DNA and associated proteins called histones, which can be transcriptionally inactive (heterochromatin) or active (euchromatin).
The difference between chromosomes and chromatin is based on the level of organization, which is associated with diverse factors that make this structure dynamic for cell division and/or transcriptional activity.
In conclusion, possible rationales for the difference between the DNA in chromatin and chromosome form are associated with the structure of chromatin, loosely organized chromatin facilitates transcription and condensed chromatin keeps the DNA organized.
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