The Columbian Exchange definitely had a one-sided illness component. The likelihood is that starting in the 1490s, syphilis emerged in the Americas and spread there.
What is the Columbian Exchange?
The two-way exchange between the Americas and Europe/Africa is known as the Columbian Exchange. During the Age of Exploration, there was a flow of products and people between the Old World and the New World.
The widespread exchange of plants, animals, cultures, human populations, technology, diseases, and ideas between the Americas, West Africa, and the Old World in the 15th and 16th centuries is referred to as the Columbian exchange, also known as the Columbian interchange.
Hence, the significance of the Columbian Exchange is aforementioned.
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